How is LUTATHERA® (lutetium Lu 177 dotatate) Given?

Once you agree to receive LUTATHERA

It’s important to tell your healthcare provider everything about your disease and health status. This should include:

  • Symptoms you may have
  • Any changes in your daily habits
  • If you are trying to get pregnant, if you are already pregnant, or breastfeeding
  • If you have trouble controlling when you urinate or have a bowel movement
  • All the medicines you are taking

It is especially important to tell your healthcare provider if you are taking a type of medicine called a somatostatin analog. If you are taking one, you might have to stop or change your treatment for a short time before and while taking LUTATHERA.

Understanding radiation

Your doctor will give you tips to minimize radiation exposure to those around you throughout your treatment with LUTATHERA.

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Reproductive safety

Females of reproductive potential must use birth control during treatment with LUTATHERA and for 7 months after the final dose. Males with female partners of re­productive potential must use birth control during treatment and for 4 months after the final dose.
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Before your first infusion

A few weeks before your first LUTATHERA infusion, your healthcare provider may conduct a few tests to make sure you are ready for treatment. They will check your liver, kidneys, and blood. Depending on the results, they may hold off on administering LUTATHERA until you are ready.
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The day of therapy

You will go to your healthcare provider’s hospital to have LUTATHERA administered. This is usually done in the nuclear medicine department. The doctors and nurses in this department are specially trained to use medicines like LUTATHERA.
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The infusion

The infusion process lasts about 5 hours.

Approximately 1 hour before you are given LUTATHERA: You will be given a medicine that will help with any vomiting or an upset stomach that you may experience because of the treatment.

30 minutes before you are given LUTATHERA: You will be given amino acids through an intravenous (IV) infusion. This will help protect your kidneys. This infusion will take at least 4 hours. It will continue during and after you receive LUTATHERA.

The LUTATHERA infusion: Will take 30 to 40 minutes and is given as an IV infusion.

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After the infusion

Because LUTATHERA treatment uses radiation, you will have to wait a short while before you can leave the hospital. The more you urinate, the faster the radiation will leave your body. A healthcare provider will let you know when it’s safe for you to leave the hospital. Within a day of receiving LUTATHERA, you will be given an injection of long-acting octreotide 30 mg.

You will receive an injection of long-acting octreotide 30 mg after each LUTATHERA infusion.

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Your next infusion

A full course of therapy consists of 4 doses of LUTATHERA. These doses will be between 8 and 16 weeks apart.

You and your healthcare provider will decide how many doses and how long between each dose is right for you.

Between each dose, your healthcare provider may check your liver, kidneys, and blood again.

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After your last dose

Your healthcare provider may check your liver, kidneys, and blood on a routine basis after your last LUTATHERA dose. You will continue receiving long-acting octreotide 30 mg until your cancer spreads, grows, or gets worse for up to 18 months since you started LUTATHERA treatment.

What is LUTATHERA?

LUTATHERA® (lutetium Lu 177 dotatate) is a prescription medicine used to treat adults with a type of cancer known as gastroenteropancreatic neuroendocrine tumors (GEP-NETs) that are positive for the hormone receptor somatostatin, including GEP-NETs in the foregut, midgut, and hindgut.

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